A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings

Research output: Contribution to journalJournal articleResearchpeer-review

A.R. Pries, H. Habazettl, G. Ambrosio, J.C. Kaski, V. Schachinger, H. Tillmanns, G. Vassalli, I. Tritto, M. Weis, Wit C. de, R. Bugiardini, Peter Riis Hansen

Obstructive disease of the large coronary arteries is the prominent cause for angina pectoris. However, angina may also occur in the absence of significant coronary atherosclerosis or coronary artery spasm, especially in women. Myocardial ischaemia in these patients is often associated with abnormalities of the coronary microcirculation and may thus represent a manifestation of coronary microvascular disease (CMD). Elucidation of the role of the microvasculature in the genesis of myocardial ischaemia and cardiac damage-in the presence or absence of obstructive coronary atherosclerosis-will certainly result in more rational diagnostic and therapeutic interventions for patients with ischaemic heart disease. Specifically targeted research based on improved assessment modalities is needed to improve the diagnosis of CMD and to translate current molecular, cellular, and physiological knowledge into new therapeutic options
Udgivelsesdato: 2008/11/1
Original languageEnglish
JournalCardiovascular Research
Volume80
Issue number2
Pages (from-to)165-174
Number of pages9
ISSN0008-6363
Publication statusPublished - 2008

ID: 13712762